Reznikov A G, Nosenko N D, Tarasenko L V, Sinitsyn P V, Poliakova L I, Mishunina T M
Ross Fiziol Zh Im I M Sechenova. 2006 Feb;92(2):238-48.
The effects of hydrocortisone acetate treatment of rats during the last gestational week on neurochemical and morphological characteristics of the brain in early postnatal and mature offspring were studied. Disappearance of sexual differences both in aromatase and 5alpha-reductase activities and noradrenaline concentration in the preoptic area in 10-day old rats was found. Meanwhile a sexual dimorphism in serotonin metabolism emerged. In adult offspring, the prenatal exposure to glucocorticoids resulted in disappearance of sexual differences in neurocytes' nuclei volume in medial preoptic and suprachiasmatic nuclei. The adrenocortical reaction to noradrenaline infusion to the 3rd brain ventricle was absent in the experimental males and intensified in females. In males, adrenocortical reaction to restraint decreased while post-stress changes in hypothalamic noradrenaline concentration and hippocampal glutamate decarboxylase activity were not observed. In the similar experiments in females both the augmentation of adrenocortical reaction and inhibition of GABA-ergic system were revealed. The results obtained indicate the modifying effect of prenatal exposure to glucocorticoids on sexual dimorphism of neuroendocrine system.
研究了在妊娠最后一周给大鼠注射醋酸氢化可的松对其出生早期及成熟子代大脑神经化学和形态学特征的影响。发现10日龄大鼠视前区芳香化酶和5α-还原酶活性以及去甲肾上腺素浓度的性别差异消失。同时，血清素代谢出现了性别二态性。在成年子代中，产前暴露于糖皮质激素导致视前内侧核和视交叉上核神经细胞核体积的性别差异消失。实验雄性大鼠对向第三脑室注入去甲肾上腺素无肾上腺皮质反应，而雌性大鼠的反应增强。在雄性大鼠中，对束缚的肾上腺皮质反应减弱，且未观察到应激后下丘脑去甲肾上腺素浓度和海马谷氨酸脱羧酶活性的变化。在雌性大鼠的类似实验中，发现肾上腺皮质反应增强且γ-氨基丁酸能系统受到抑制。所得结果表明产前暴露于糖皮质激素对神经内分泌系统性别二态性具有调节作用。
