Reznikov Alexander, Nosenko Nadezhda, Tarasenko Larisa, Sinitsyn Petr, Polyakova Lyubov, Mishunina Tamara
Department of Endocrinology of Reproduction and Adaptation, V.P. Komissarenko Institute of Endocrinology and Metabolism, Kiev 04114, Ukraine.
Exp Toxicol Pathol. 2008 Sep;60(6):489-97. doi: 10.1016/j.etp.2008.05.004. Epub 2008 Aug 9.
We investigated the effects of hydrocortisone acetate administered to pregnant rats over the last gestational week on some neuroendocrine characteristics in adult female and male offspring. Prenatal glucocorticoid eliminated sex dimorphism of the neurons nuclei volumes in the medial preoptic area and the suprachiasmatic nuclei. There was no elevation of blood plasma corticosterone level after noradrenaline infusion into the third brain ventricle in experimental males; meanwhile, in females adrenocortical response was augmented. Male offspring exhibited a decrease of plasma corticosterone response to an acute stress (1h restraint) that was not accompanied by post-stress changes neither in the hypothalamic noradrenaline content nor hippocampal glutamate decarboxylase activity. On the contrary, moderate augmentation of adrenocortical stress reactivity and inhibitory effect of GABAergic system were found in females. It was concluded that exposure to prenatal glucocorticoid is able to alter development of the neuroendocrine systems related to reproduction and stress responses both in males and females and resulted in modification of its sex-dimorphic features in adult life.
我们研究了在妊娠最后一周给怀孕大鼠注射醋酸氢化可的松对成年雌性和雄性后代某些神经内分泌特征的影响。产前糖皮质激素消除了视前内侧区和视交叉上核中神经元细胞核体积的性别二态性。在实验雄性大鼠中，向第三脑室注入去甲肾上腺素后，血浆皮质酮水平没有升高；与此同时，雌性大鼠的肾上腺皮质反应增强。雄性后代对急性应激（1小时束缚）的血浆皮质酮反应降低，应激后下丘脑去甲肾上腺素含量和海马谷氨酸脱羧酶活性均无变化。相反，在雌性大鼠中发现肾上腺皮质应激反应性适度增强，且γ-氨基丁酸能系统具有抑制作用。研究得出结论，产前接触糖皮质激素能够改变与生殖和应激反应相关的神经内分泌系统的发育，并导致成年后其性别二态性特征发生改变。
