Goldberg David
Institute of Psychiatry, King's College, London, UK.
Psychol Med. 2006 Oct;36(10):1341-7. doi: 10.1017/S0033291706007665. Epub 2006 Jun 2.
This review will start by considering studies of the genetic contribution to the liability to depression, and go on to consider some of the ways in which environmental factors can modify gene expression. This will lead on to the pathways by which the genetic factors also appear to control stressful life events in adolescence and adult life, and then to a consideration of causes that are entirely environmental. We will conclude by considering the causes of the gender differences in the prevalence of depression during adult life.
本综述将首先探讨关于遗传因素对抑郁症易感性影响的研究，接着思考环境因素能够改变基因表达的一些方式。这将引出遗传因素似乎也在控制青少年和成年期应激性生活事件的途径，然后再探讨完全由环境导致的病因。最后，我们将思考成年期抑郁症患病率存在性别差异的原因。
