Vedamurthachar A, Janakiramaiah Nimmagadda, Hegde Jayaram M, Shetty Taranath K, Subbakrishna D K, Sureshbabu S V, Gangadhar B N
National Institute of Mental Health and Neurosciences, Bangalore, India.
J Affect Disord. 2006 Aug;94(1-3):249-53. doi: 10.1016/j.jad.2006.04.025. Epub 2006 Jun 5.
Sudarshana Kriya Yoga (SKY) has demonstrable antidepressant effects. SKY was tested for this effect in inpatients of alcohol dependence.
Following a week of detoxification management consenting subjects (n=60) were equally randomized to receive SKY therapy or not (controls) for a two-week study. SKY therapy included alternate day practice of specified breathing exercise under supervision of a trained therapist. Subjects completed the Beck Depression Inventory (BDI) before and after the two weeks of this intervention. Morning plasma cortisol, ACTH and prolactin too were measured before and at the end of two weeks.
In both groups reductions in BDI scores occurred but significantly more so in SKY group. Likewise, in both groups plasma cortisol as well as ACTH fell after two weeks but significantly more so in SKY group. Reduction in BDI scores correlated with that in cortisol in SKY but not in control group.
Antidepressant effects of SKY were demonstrated in early abstinence that also had substantial spontaneous improvement. It is not known if this effect contributes to sustained abstinence.
Results extend the antidepressant effects of SKY in alcohol dependence subjects. Reduction in stress-hormone levels (cortisol and ACTH) along with BDI reductions possibly support a biological mechanism of SKY in producing beneficial effects.
苏达山克里亚瑜伽（SKY）具有显著的抗抑郁作用。本研究在酒精依赖住院患者中对SKY的这种作用进行了测试。
在一周的脱毒管理后，60名同意参与的受试者被随机分为两组，每组30人，一组接受SKY疗法，另一组作为对照组，进行为期两周的研究。SKY疗法包括在经过培训的治疗师监督下，隔天进行特定的呼吸练习。在干预的两周前后，受试者完成贝克抑郁量表（BDI）测试。同时，在两周干预开始前和结束时测量早晨血浆皮质醇、促肾上腺皮质激素（ACTH）和催乳素水平。
两组的BDI评分均有所降低，但SKY组的降低更为显著。同样，两组的血浆皮质醇和ACTH在两周后均下降，但SKY组下降更为明显。SKY组中BDI评分的降低与皮质醇的降低相关，而对照组则无此相关性。
SKY的抗抑郁作用在早期戒酒阶段得到证实，而这一阶段本身也有显著的自发改善。尚不清楚这种作用是否有助于维持戒酒状态。
研究结果扩展了SKY对酒精依赖患者的抗抑郁作用。应激激素水平（皮质醇和ACTH）的降低以及BDI评分的降低可能支持了SKY产生有益作用的生物学机制。
