Institute of Physical Education, Xinjiang Normal University, Urumqi, Xinjiang, China.
Institute of Physical Education, Jishou University, Jishou, Hunan, China.
PLoS One. 2024 Oct 30;19(10):e0311166. doi: 10.1371/journal.pone.0311166. eCollection 2024.
This meta-analysis and systematic review examined the effects of an exercise intervention on alcohol dependence and physical and mental states in patients with alcohol use disorder (AUD).
PubMed, Web of Science, Cochrane Library, EBSCO, and Embase.
Randomized controlled trials published in English from the inception of the database until June 30, 2024, were included. All forms of exercise intervention (aerobic, resistance, yoga, mixed exercise, etc.) were included in the study, using an exercise intervention for patients with AUD and a non-exercise control group. Studies that excluded acute exercise or did not describe a specific intervention program; duplicate publications; review articles, conference articles, etc.; and studies that did not report appropriate outcome metrics.
This protocol was prepared according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol standard. The risk of bias was assessed via the Cochrane risk-of-bias tool as described by the Cochrane Handbook for Systematic Reviews and Interventions.
Alcohol dependence (number of drinks per day, number of drinks per week, AUDIT), physical and mental status [maximal oxygen uptake (VO2 max), resting heart rate, anxiety state, depression state, stress level].
Seventeen RCTs with a total of 1,905 patients with alcohol use disorders were included as subjects, and the results revealed that the exercise intervention had a significant effect on alcohol dependence, the number of drinks per day and the AUDIT score, the exercise intervention also had a significant effect on physical and mental status, VO2max, the resting heart rate, the anxiety state, the depression state, and the stress level. High heterogeneity in the number of drinks per day, anxiety, depression and stress outcomes (I2 > 50%), but Egger's test showed no publication bias for all outcome indicators (p > 0.05).
Exercise intervention can effectively reduce alcohol dependence and significantly improve the physical and mental states of AUD patients, and exercise intervention as an adjunct to the treatment of AUD patients is significantly effective.
本荟萃分析和系统评价考察了运动干预对酒精使用障碍（AUD）患者的酒精依赖和身心状态的影响。
PubMed、Web of Science、Cochrane Library、EBSCO 和 Embase。
纳入了自数据库建立至 2024 年 6 月 30 日发表的英文随机对照试验。研究纳入了所有形式的运动干预（有氧运动、抗阻运动、瑜伽、混合运动等），使用运动干预治疗 AUD 患者和非运动对照组。排除了急性运动或未描述特定干预方案的研究；重复发表的研究；综述文章、会议文章等；以及未报告适当结局指标的研究。
本方案按照系统评价和荟萃分析首选报告项目的标准制定。使用 Cochrane 手册中描述的 Cochrane 偏倚风险工具评估偏倚风险。
酒精依赖（每日饮酒量、每周饮酒量、AUDIT）、身心状态[最大摄氧量（VO2 max）、静息心率、焦虑状态、抑郁状态、应激水平]。
纳入了 17 项 RCT，共纳入 1905 名酒精使用障碍患者，结果显示运动干预对酒精依赖、每日饮酒量和 AUDIT 评分有显著影响，运动干预对身心状态、VO2 max、静息心率、焦虑状态、抑郁状态和应激水平也有显著影响。每日饮酒量、焦虑、抑郁和应激结局的异质性较高（I2 > 50%），但 Egger 检验显示所有结局指标均无发表偏倚（p > 0.05）。
运动干预可有效降低酒精依赖，显著改善 AUD 患者的身心状态，运动干预作为 AUD 患者治疗的辅助手段具有显著效果。
