舒张期限制性充盈可预测急性心肌梗死后的死亡：前瞻性研究的系统评价和荟萃分析
Restrictive diastolic filling predicts death after acute myocardial infarction: systematic review and meta-analysis of prospective studies.
作者信息
Whalley G A, Gamble G D, Doughty R N
机构信息
Department of Medicine, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand.
出版信息
Heart. 2006 Nov;92(11):1588-94. doi: 10.1136/hrt.2005.083055. Epub 2006 Jun 1.
Abstract
OBJECTIVE
To determine, through a systematic review and meta-analysis, the magnitude of the survival deficit associated with a restrictive filling pattern after acute myocardial infarction (AMI).
METHODS
Online databases were searched for prospective echocardiography outcome studies of patients after AMI. All authors were contacted to seek confirmation of their data. Restrictive filling was compared with all non-restrictive filling patterns. Review Manager Version 4.2.7 software was used for analysis.
RESULTS
3855 patients in 16 studies were identified. Follow up varied from two weeks to five years (> 1 year, 10 studies; and > 4 years, four studies). 776 (20%) of patients had a restrictive filling pattern at baseline. 580 patients died (247 in the restrictive group), and the overall odds ratio for death (restrictive filling worse) was 4.10 (95% confidence interval 3.38 to 4.99).
CONCLUSIONS
Mortality is about four times higher in patients with a restrictive filling pattern than in those with non-restrictive filling patterns after AMI. Echocardiographic assessment of diastolic filling pattern is an important part of the echocardiographic assessment of patients after myocardial infarction and provides important prognostic information about such patients.
摘要
目的
通过系统评价和荟萃分析，确定急性心肌梗死（AMI）后与限制性充盈模式相关的生存缺陷程度。
方法
检索在线数据库，查找AMI后患者的前瞻性超声心动图结局研究。联系所有作者以确认其数据。将限制性充盈与所有非限制性充盈模式进行比较。使用Review Manager 4.2.7版软件进行分析。
结果
16项研究中识别出3855例患者。随访时间从2周到5年不等（>1年，10项研究；>4年，4项研究）。776例（20%）患者在基线时有限制性充盈模式。580例患者死亡（限制性组247例），死亡的总体比值比（限制性充盈更差）为4.10（95%置信区间3.38至4.99）。
结论
AMI后，限制性充盈模式患者的死亡率约是非限制性充盈模式患者的四倍。舒张期充盈模式的超声心动图评估是心肌梗死后患者超声心动图评估的重要组成部分，并为此类患者提供重要的预后信息。
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