Kawasaki H, Nakamura S, Takasaki K
Department of Pharmacology, Miyazaki Medical College, Japan.
Neurosci Lett. 1991 Feb 25;123(2):232-5. doi: 10.1016/0304-3940(91)90938-p.
The effect of somatostatin on the hypertensive response induced by intracerebroventricular (i.c.v.) injection of clonidine was investigated in freely moving rats. A 10 micrograms i.c.v. injection of clonidine produced a marked pressor response and a decrease in heart rate. No depressor response was induced by clonidine. The i.c.v. pretreatment with somatostatin (2 and 5 micrograms) dose-dependently inhibited the pressor response to i.c.v. injected clonidine (10 micrograms), and a long-lasting depressor response was observed. Systemic (i.v.) treatment with somatostatin had no such effect. These results suggest that brain somatostatin modulates the centrally-mediated pressor response to clonidine.
