Nakamura S, Kawasaki H, Takasaki K
Department of Pharmacology, Miyazaki Medical College, Japan.
Jpn J Pharmacol. 1991 Nov;57(3):443-6. doi: 10.1254/jjp.57.443.
Effects of intracerebroventricular (i.c.v.) treatment with atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) on the pressor response to i.c.v.-injected clonidine were investigated in conscious rats. I.c.v.-pretreatment with ANP (10 micrograms) or BNP (10 micrograms) inhibited the pressor response to i.c.v.-injected clonidine (10 micrograms). Systemic (i.v.) treatment with ANP and BNP had no such effect. These results suggest that natriuretic peptides in the brain modulate the centrally mediated pressor response to clonidine.
在清醒大鼠中，研究了脑室内（i.c.v.）注射心房利钠肽（ANP）和脑利钠肽（BNP）对i.c.v.注射可乐定的升压反应的影响。用ANP（10微克）或BNP（10微克）进行i.c.v.预处理可抑制对i.c.v.注射可乐定（10微克）的升压反应。用ANP和BNP进行全身（静脉）治疗则无此效果。这些结果表明，脑中的利钠肽可调节对可乐定的中枢介导的升压反应。
