淋巴细胞功能相关抗原-1（LFA-1）在HIV感染中的作用：单克隆抗体的抑制作用
Involvement of lymphocyte function-associated antigen-1 (LFA-1) in HIV infection: inhibition by monoclonal antibody.
作者信息
Hansen J E, Nielsen C, Mathiesen L R, Nielsen J O
机构信息
Department of Infectious Diseases, Hvidovre Hospital, Denmark.
出版信息
Scand J Infect Dis. 1991;23(1):31-6. doi: 10.3109/00365549109023371.
Monoclonal antibodies (MAbs) against the alpha- and beta-chain of lymphocyte-associated antigen-1 (LFA-1) were examined for inhibition of HIV-1 infection in vitro. Infection of the T cell line MT4 and the monocytic cell line U937 by isolates HTLVIIIB and SSI-002, respectively was inhibited in a concentration dependent manner by MAb against the beta-chain but not against the alpha-chain. No cross-reactivity was found between MAb against LFA-1 and against the CD4 receptor (MAb Leu3a). MAbs against the beta-chain and the CD4 receptor were found to act synergistically in inhibiting HIV infection. These data indicate that the beta-chain of LFA-1 in addition to the CD4 receptor may be involved in HIV infection in vitro.
检测了针对淋巴细胞相关抗原-1（LFA-1）α链和β链的单克隆抗体（MAb）在体外对HIV-1感染的抑制作用。分别用针对β链而非α链的单克隆抗体以浓度依赖的方式抑制了分离株HTLVIIIB和SSI-002对T细胞系MT4和单核细胞系U937的感染。未发现针对LFA-1的单克隆抗体与针对CD4受体的单克隆抗体（MAb Leu3a）之间存在交叉反应。发现针对β链的单克隆抗体和针对CD4受体的单克隆抗体在抑制HIV感染方面具有协同作用。这些数据表明，除CD4受体外，LFA-1的β链可能也参与了体外HIV感染。
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