血清中的体重指数和肝酶活性

Body mass index and liver enzyme activity in serum.

作者信息

Salvaggio A, Periti M, Miano L, Tavanelli M, Marzorati D

机构信息

Clinica Medica Generale, University of Milan, Italy.

出版信息

Clin Chem. 1991 May;37(5):720-3.

PMID:1674452

Abstract

The association between body mass index (BMI) and serum liver enzyme activity [gamma-glutamyltransferase (GGT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST)] was studied in 3167 subjects, 2373 men and 794 women. The subjects were managers and employees, ages 18-64 years, who were examined during a program of preventive medicine. Analysis of covariance was used to compare the serum liver enzyme activities (expressed as natural logarithms) of the subjects, who were subdivided according to BMI, while also considering age, alcohol and cigarette consumption, and physical activity. In men, the percentage increase in the geometric mean of liver enzyme activity of the obese subjects (BMI greater than 30 kg/m2) compared with that of the normal subjects (BMI less than or equal to 25 kg/m2) was 47.7% (P less than 0.001) for GGT, 55.3% (P less than 0.001) for ALT, and 19.7% (P less than 0.001) for AST; in women, the increase was 63.2% (P less than 0.01) for GGT, 58.4% (P less than 0.001) for ALT, and 7.3% (P greater than 0.05) for AST. Thus, our observations demonstrate a relation between BMI and serum liver enzyme activity.

摘要

在3167名受试者（2373名男性和794名女性）中研究了体重指数（BMI）与血清肝酶活性[γ-谷氨酰转移酶（GGT）、丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）]之间的关联。这些受试者为年龄在18至64岁之间的管理人员和员工，他们在一项预防医学项目中接受了检查。采用协方差分析比较了根据BMI细分的受试者的血清肝酶活性（以自然对数表示），同时考虑了年龄、酒精和香烟消费以及身体活动。在男性中，肥胖受试者（BMI大于30kg/m²）的肝酶活性几何平均值相较于正常受试者（BMI小于或等于25kg/m²）的几何平均值增加的百分比，GGT为47.7%（P<0.001），ALT为55.3%（P<0.001），AST为19.7%（P<0.001）；在女性中，GGT增加63.2%（P<0.01），ALT增加58.4%（P<0.001），AST增加7.3%（P>0.05）。因此，我们的观察结果表明BMI与血清肝酶活性之间存在关联。