Levant B, Bissette G, Widerlöv E, Nemeroff C B
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710.
Regul Pept. 1991 Feb 1;32(2):193-201. doi: 10.1016/0167-0115(91)90046-j.
Classical antipsychotic drugs, such as haloperidol, have been shown to increase the concentrations of neurotensin (NT) selectively in the nucleus accumbens and caudate nucleus of the rat. Several novel, putative antipsychotic drugs have also been found to produce increases in NT content in one or both of these brain regions. The present study sought to compare the effects of chronic treatment with three clinically efficacious atypical antipsychotic drugs, sulpiride, rimcazole and remoxipride, on regional brain NT concentrations to those of haloperidol. The concentrations of NT in five discrete brain regions were determined by a sensitive and specific radioimmunoassay. As previously reported, haloperidol increased NT concentrations in both the nucleus accumbens and caudate nucleus. Sulpiride and rimcazole produced significant increases in the concentration of NT in the caudate. NT concentrations were unaltered in any brain region by remoxipride at either of the doses tested. These data provide additional evidence for specific increases in regional brain NT concentrations produced by antipsychotic drugs.
经典抗精神病药物，如氟哌啶醇，已被证明可选择性增加大鼠伏隔核和尾状核中神经降压素（NT）的浓度。还发现几种新型的、假定的抗精神病药物会使这两个脑区中的一个或两个脑区的NT含量增加。本研究旨在比较三种临床有效的非典型抗精神病药物舒必利、利咪唑和瑞莫必利长期治疗对脑区NT浓度的影响与氟哌啶醇的影响。通过灵敏且特异的放射免疫分析法测定五个离散脑区中NT的浓度。如先前报道，氟哌啶醇增加了伏隔核和尾状核中的NT浓度。舒必利和利咪唑使尾状核中NT的浓度显著增加。在所测试的任一剂量下，瑞莫必利均未改变任何脑区的NT浓度。这些数据为抗精神病药物引起的脑区NT浓度特异性增加提供了更多证据。
