Labie C, Keane P E, Soubrié P, Le Fur G
Sanofi Recherche, Toulouse, France.
Eur J Pharmacol. 1993 Feb 16;231(3):465-7. doi: 10.1016/0014-2999(93)90125-2.
The effects of SR 31742A, a specific sigma site ligand, were investigated on regional neurotensin concentrations in rat brain. Both acute and chronic (21-day) treatment with either SR 31742A (20 mg/kg i.p.) or haloperidol (1 mg/kg i.p.) increased the neurotensin-like immunoreactivity in the nucleus accumbens. In contrast to haloperidol, the administration of SR 31742A failed to increase the concentration of neurotensin-like immunoreactivity in the caudate-putamen. Thus, the effects of SR 31742A appear to be selective for the limbic system.
研究了特异性σ位点配体SR 31742A对大鼠脑内局部神经降压素浓度的影响。用SR 31742A（腹腔注射20mg/kg）或氟哌啶醇（腹腔注射1mg/kg）进行急性和慢性（21天）处理，均可增加伏隔核中神经降压素样免疫反应性。与氟哌啶醇不同，SR 31742A给药未能增加尾状核-壳核中神经降压素样免疫反应性的浓度。因此，SR 31742A的作用似乎对边缘系统具有选择性。
