马体内γ-谷氨酰转移酶的组织分布及血药浓度

Tissue distribution and blood levels of gamma-glutamyl transferase in the horse.

作者信息

Rico A G, Braun J P, Benard P, El Hassan A A, Cazieux A

出版信息

Equine Vet J. 1977 Apr;9(2):100-1. doi: 10.1111/j.2042-3306.1977.tb03995.x.

DOI:10.1111/j.2042-3306.1977.tb03995.x

Abstract

In the horse, gamma-glutamyl transferase (GGT) was found to be mainly located in the kidneys, liver and pancreas. As renal lesions are followed by a urinary escape of enzyme, it can be assumed that if there are raised serum enzyme levels then the source will be chiefly from the liver and pancreas. In the blood, GGT can be measured either in plasma or serum. Its mean level in 58 horses was 12 U/L. This level was not affected by moderate dilution or slight haemolysis and its activity was only slightly decreased by storage at--30 degrees C. The relative hepatic specificity of this enzyme and its easy measurement make it a potentially very useful measure of liver dysfunction in the horse.

摘要

在马身上，发现γ-谷氨酰转移酶（GGT）主要位于肾脏、肝脏和胰腺。由于肾脏病变会导致酶从尿液中逸出，可以推测，如果血清酶水平升高，那么其来源主要是肝脏和胰腺。在血液中，GGT可以在血浆或血清中进行测量。58匹马的GGT平均水平为12 U/L。该水平不受适度稀释或轻微溶血的影响，并且在-30℃储存时其活性仅略有下降。这种酶的相对肝脏特异性及其易于测量的特点使其成为检测马肝脏功能障碍的一种潜在非常有用的指标。