Lesch K P, Hoh A, Disselkamp-Tietze J, Wiesmann M, Osterheider M, Schulte H M
Department of Psychiatry, University of Würzburg, Germany.
Arch Gen Psychiatry. 1991 Jun;48(6):540-7. doi: 10.1001/archpsyc.1991.01810300052007.
To evaluate 5-hydroxytryptamine1A receptor responsivity in obsessive-compulsive disorder, we examined hypothermic, neuroendocrine, and behavioral responses to the selective 5-hydroxytryptamine1A receptor ligand ipsapirone in patients with primary obsessive-compulsive disorder and healthy controls. Twelve patients and 22 controls received a single dose of ipsapirone, 0.3 mg/kg, or placebo under double-blind, random assignment conditions. Ipsapirone induced hypothermia and release of corticotropin and cortisol but had no effect on behavior, including obsessive or compulsive symptoms. Thermoregulatory and neuroendocrine responses to ipsapirone were not consistently different between healthy controls and patients with obsessive-compulsive disorder. These results provide no direct support for the hypothesis that a serotonergic dysfunction related to 5-hydroxytryptamine1A receptors may be linked to the pathophysiologic characteristics of obsessive-compulsive disorder and point to the need for the evaluation of other 5-hydroxytryptamine receptor subtypes. Future studies of the responsivity of 5-hydroxytryptamine1A receptors to direct-acting ligands, such as ipsapirone, should facilitate assessment of the integrity of the 5-hydroxytryptamine system and its involvement in antiobsessional drug effects.
为评估强迫症患者中5-羟色胺1A受体的反应性，我们检测了原发性强迫症患者和健康对照者对选择性5-羟色胺1A受体配体伊沙匹隆的体温降低、神经内分泌及行为反应。12例患者和22例对照在双盲、随机分配条件下接受了单剂量的伊沙匹隆（0.3mg/kg）或安慰剂。伊沙匹隆可引起体温降低以及促肾上腺皮质激素和皮质醇释放，但对行为包括强迫症状没有影响。健康对照者和强迫症患者对伊沙匹隆的体温调节和神经内分泌反应并无持续差异。这些结果并不直接支持与5-羟色胺1A受体相关的5-羟色胺能功能障碍可能与强迫症病理生理特征有关的假说，并指出需要评估其他5-羟色胺受体亚型。未来关于5-羟色胺1A受体对直接作用配体（如伊沙匹隆）反应性的研究，应有助于评估5-羟色胺系统的完整性及其在抗强迫药物效应中的作用。
