Lesch K P, Mayer S, Disselkamp-Tietze J, Hoh A, Schoellnhammer G, Schulte H M
Department of Psychiatry, University of Wuerzburg, FRG.
Life Sci. 1990;46(18):1271-7. doi: 10.1016/0024-3205(90)90359-y.
The selective 5-HT1A receptor ligand ipsapirone (IPS) induces hypothermia in humans. To explore 5-HT1A receptor-mediated thermoregulation in depression, 24 subjects (12 patients with unipolar depression and 12 individually matched controls) received 0.3 mg/kg IPS or placebo in random order. Compared with controls, the depressed patients exhibited significantly attenuated hypothermic responses to IPS. The impaired hypothermic response following 5-HT1A receptor activation in unipolar depression could have resulted from subsensitivity of the (presynaptic) 5-HT1A receptor and/or related effector mechanisms, thus supporting the hypothesis that altered serotonergic activity may be present in affective disorders. Future studies of the hypothermic response to direct-acting 5-HT1A ligands, such as IPS should facilitate the assessment of 5-HT receptor function in various affective disorders and its involvement in psychotropic drug effects.
选择性5-羟色胺1A（5-HT1A）受体配体伊沙匹隆（IPS）可使人体体温降低。为探究5-HT1A受体介导的体温调节在抑郁症中的作用，24名受试者（12名单相抑郁症患者和12名个体匹配的对照者）随机接受0.3mg/kg的IPS或安慰剂。与对照组相比，抑郁症患者对IPS的体温降低反应明显减弱。单相抑郁症患者5-HT1A受体激活后体温降低反应受损，可能是由于（突触前）5-HT1A受体和/或相关效应机制的敏感性降低所致，从而支持了情感障碍中可能存在血清素能活性改变的假说。未来对直接作用的5-HT1A配体（如IPS）体温降低反应的研究，应有助于评估5-HT受体在各种情感障碍中的功能及其在精神药物作用中的参与情况。
