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1
A method for the estimation of 6-oxygenated metabolites of progesterone in urine.一种测定尿中孕酮6-氧代代谢物的方法。
Biochem J. 1965 May;95(2):459-65. doi: 10.1042/bj0950459.
2
Quantifying endogenous androgens, estrogens, pregnenolone and progesterone metabolites in human urine by gas chromatography tandem mass spectrometry.应用气相色谱-串联质谱法对人尿液中内源性雄激素、雌激素、孕烯醇酮和孕酮代谢物进行定量分析。
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3
Effects of beta-naphthoflavone and 3-methylcholanthrene administered to pregnant rats on steroid metabolism in the isolated basal zone of the placenta.
J Pharmacol Exp Ther. 1984 Sep;230(3):761-7.
4
Urinary excretion of 5beta-pregnane-3alpha,20alpha,21-triol in human gestation.人妊娠期尿中5β-孕烷-3α,20α,21-三醇的排泄情况
Biomed Mass Spectrom. 1978 Mar;5(3):184-7. doi: 10.1002/bms.1200050304.
5
Characterization of oxygenated metabolites of ginsenoside Rg1 in plasma and urine of rat.大鼠血浆和尿液中人参皂苷Rg1氧化代谢产物的表征
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Temporal changes in activities of enzymes reducing ring-A of progesterone in the fetus and placenta of the rat.
Endocrinology. 1976 Jul;99(1):249-59. doi: 10.1210/endo-99-1-249.
7
Influence of Ethynodiol Diacetate on the Formation of A-Homo-3Oxa-5?-Pregnane-4,20-Dione in Female Rats.双醋炔诺醇对雌性大鼠中A-高-3-氧杂-5α-孕烷-4,20-二酮形成的影响
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Elucidation of Neu-P11 metabolism in urine of volunteers by liquid chromatography-tandem mass spectrometry.应用液质联用技术阐明志愿者尿液中的 Neu-P11 代谢产物。
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9
Fecal progesterone, estrogen, and androgen metabolites for noninvasive monitoring of reproductive function in the female Indian rhinoceros, Rhinoceros unicornis.用于非侵入性监测雌性印度犀（独角犀）生殖功能的粪便孕酮、雌激素和雄激素代谢物
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A method for the estimation of urinary testosterone.一种估算尿睾酮的方法。
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引用本文的文献

1
Zimmermann reaction of 3-, 6- and 20-oxosteroids.3-、6-和20-氧代甾体的齐默尔曼反应。
Experientia. 1967 Apr 15;23(4):288-9. doi: 10.1007/BF02135692.

本文引用的文献

1
THE BIOCHEMISTRY OF PROGESTERONE.孕酮的生物化学
Vitam Horm. 1964;22:153-204. doi: 10.1016/s0083-6729(08)60339-8.
2
THE METABOLISM OF PROGESTERONE IN MAN. EXTRACTION AND SEPARATION BY COUNTERCURRENT DISTRIBUTION OF THE METABOLITES IN URINE.人体内孕酮的代谢。通过逆流分配法对尿液中代谢产物进行提取与分离。
Biochem J. 1963 Aug;88(2):308-14. doi: 10.1042/bj0880308.
3
Metabolism of progesterone-4-C14 in young and elderly men.
J Clin Endocrinol Metab. 1963 Mar;23:286-92. doi: 10.1210/jcem-23-3-286.
4
Separation and quantitative determination of progesterone and pregnenolone.孕酮和孕烯醇酮的分离与定量测定。
J Biol Chem. 1952 Oct;198(2):713-9.

一种测定尿中孕酮6-氧代代谢物的方法。

A method for the estimation of 6-oxygenated metabolites of progesterone in urine.

作者信息

James F, Fotherby K

机构信息

Postgraduate Medical School, Ducane Road, London, W. 12.

出版信息

Biochem J. 1965 May;95(2):459-65. doi: 10.1042/bj0950459.

DOI:10.1042/bj0950459
PMID:16749079
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1214344/
Abstract
  1. A method is described for the estimation of the 6-oxygenated metabolites of progesterone in urine. After hydrolysis the extract of urine is chromatographed on alumina to obtain a fraction containing mainly the 6-oxygenated metabolites. This fraction is oxidized to convert the metabolites into pregnane-3,6,20-triones, which are estimated as the dinitrophenylhydrazones. 2. The reliability criteria of the method are presented. Normal subjects excrete 0.1-0.6mg./day, and at the end of pregnancy values of 3.3-11.6mg./day are obtained.
摘要
  1. 本文描述了一种估算尿中孕酮6-氧化代谢物的方法。尿液提取物经水解后在氧化铝上进行色谱分离，以获得主要含有6-氧化代谢物的馏分。该馏分被氧化，将代谢物转化为孕烷-3,6,20-三酮，以二硝基苯腙形式进行估算。2. 给出了该方法的可靠性标准。正常受试者每日排泄量为0.1 - 0.6毫克，妊娠末期的值为每日3.3 - 11.6毫克。