Check J H, Dietterich C, Lauer C, Liss J
Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Camden.
Int J Fertil. 1991 Mar-Apr;36(2):108-12.
Ovulation disorder as a possible cause of a cervical factor problem was evaluated in 30 patients with poor postcoital tests. The diagnosis of an ovulatory defect was based on follicular maturation studies included in serial pelvic ultrasonography and serial assays of serum estradiol and progesterone. Patients were divided into three groups with cervical factor presumably due to (1) immature follicular development, (2) premature luteinization, and (3) pure cervical factor. A higher pregnancy rate was achieved in the group with pure cervical factor when the therapy was directed exclusively toward improving the cervical mucus. However, a significant improvement in pregnancy rate was observed when therapy was aimed at correcting both abnormal follicular maturation and the cervical mucus problem. Combined use of pelvic sonography and quantitation of serum estradiol and progesterone allow the clinician to select the treatment for cervical factor that is most likely to achieve successful pregnancy.
在30例性交后试验结果不佳的患者中，对排卵障碍作为宫颈因素问题的可能原因进行了评估。排卵缺陷的诊断基于连续盆腔超声检查中包含的卵泡成熟研究以及血清雌二醇和孕酮的连续检测。患者被分为三组，宫颈因素可能是由于（1）卵泡发育不成熟，（2）过早黄素化，以及（3）单纯宫颈因素。当治疗仅针对改善宫颈黏液时，单纯宫颈因素组的妊娠率更高。然而，当治疗旨在纠正异常卵泡成熟和宫颈黏液问题时，观察到妊娠率有显著提高。盆腔超声检查与血清雌二醇和孕酮定量的联合使用使临床医生能够选择最有可能实现成功妊娠的宫颈因素治疗方法。
