Murillo A, Carranza-Lira S, Matienzo F, Montero J, Rodríguez M L, Murrieta S, Merino G, Morán C
Hospital de Ginecología y Obstetricia Luis Castelazo Ayala Servicio de Ginecología Endocrina, Instituto Mexicano del Seguro Social, México, D.F.
Ginecol Obstet Mex. 1995 Mar;63:115-8.
Post coital sperm penetration tests performed in 66 women under study for infertility, the purpose was to evaluate the ovulation induction effect over mucus quality and over sperm penetration. They were divided in three groups: 1) 28 women with evidence of spontaneous ovulation (control group), 2) 26 patients in which ovulation was induced with comiphene citrate and 3) 12 patients in which ovulation was induced with menotropins. The results showed that CC had an adverse effect over cervical mucus (p < 0.001), while in patients treated with menotropins the cervical mucus quality was not modified. Sperm penetration in patients under CC had a tendency to lower values than those in women of the control group, but these were statistically lower than those in patients under menotropins (p < 0.05). These results show the adverse effect of CC and the benefit of menotropins over cervical mucus and sperm penetration.
对66名接受不孕症研究的女性进行了性交后精子穿透试验，目的是评估促排卵对黏液质量和精子穿透的影响。她们被分为三组：1）28名有自发排卵证据的女性（对照组），2）26名用枸橼酸氯米芬诱导排卵的患者，3）12名用人绒毛膜促性腺激素诱导排卵的患者。结果显示，氯米芬对宫颈黏液有不良影响（p<0.001），而用人绒毛膜促性腺激素治疗的患者宫颈黏液质量未改变。接受氯米芬治疗的患者的精子穿透率有低于对照组女性的趋势，但在统计学上低于接受人绒毛膜促性腺激素治疗的患者（p<0.05）。这些结果表明氯米芬的不良影响以及人绒毛膜促性腺激素对宫颈黏液和精子穿透的益处。
