Imarhiagbe F, Ogunrin O, Ogunniyi A
Department of Medicine, University of Benin Teaching Hospital, Benin City, Nigeria.
Afr J Med Med Sci. 2005 Sep;34(3):269-73.
The importance and contribution of optimal blood pressure control to improvement in quality of life, cognitive abilities inclusive, have been established and accepted by all and sundry. In the elderly population, however, hypertension and cognitive dysfunction are commonly encountered disorders. The objective is to determine the role of blood pressure on the cognitive performances of Nigerian elderly hypertensive patients. A total of 327 randomly selected elderly subjects above 60 years of age comprising 153 hypertensive: 53 males (34.64%) and 100 females (65.36%) with a mean age of 66.65 +/- 6.64 years; and 174 normotensive healthy controls: 63 males (36.21%) and 111 females (63.79%) with a mean age of 67.29 +/- 6.45 years were studied. The mean blood pressure for the hypertensive was 160/110mmHg (range 150/94 - 190/130mmHg) while it was 120/74mmHg (range 110/50 - 139/89mmHg) for the normotensives. The cognitive testing was done with the Community Screening Instrument for Dementia (CSI'D'). The main outcome measures were cognitive test scores (CSI'D' scores) and blood pressure readings. The CSI'D' scores correlated significantly with higher educational level (P < 0.05; P = 0.0372) but the mean CSI'D' scores of hypertensives was not significantly different from that of normotensives (P>0.05). The diastolic blood pressure was the strongest predictor of the presence of cognitive impairment with a statistically significant linear relationship (P = 0.013). This study assessed the effect of blood pressure on cognitive performance. The evidence from the study showed that blood pressure has no effect on cognitive performance of subjects generally but among hypertensive subjects, diastolic blood pressure negatively correlates with cognitive performance.
最佳血压控制对包括认知能力在内的生活质量改善的重要性和贡献已得到所有人的认可。然而，在老年人群中，高血压和认知功能障碍是常见的疾病。目的是确定血压对尼日利亚老年高血压患者认知表现的作用。总共随机选择了327名60岁以上的老年受试者，其中包括153名高血压患者：53名男性（34.64%）和100名女性（65.36%），平均年龄为66.65±6.64岁；以及174名血压正常的健康对照者：63名男性（36.21%）和111名女性（63.79%），平均年龄为67.29±6.45岁。高血压患者的平均血压为160/110mmHg（范围150/94 - 190/130mmHg），而血压正常者为120/74mmHg（范围110/50 - 139/89mmHg）。认知测试采用社区痴呆筛查工具（CSI'D'）进行。主要观察指标为认知测试分数（CSI'D'分数）和血压读数。CSI'D'分数与较高的教育水平显著相关（P < 0.05；P = 0.0372），但高血压患者的平均CSI'D'分数与血压正常者无显著差异（P>0.05）。舒张压是认知障碍存在的最强预测因素，具有统计学显著的线性关系（P = 0.013）。本研究评估了血压对认知表现的影响。研究证据表明，血压总体上对受试者的认知表现没有影响，但在高血压受试者中，舒张压与认知表现呈负相关。
