Akinyemi Rufus O, Okubadejo Njideka N, Akinyemi Joshua O, Owolabi Mayowa O, Owolabi Lukman F, Ogunniyi Adesola
Division of Neurology, Department of Medicine, Federal Medical Centre, Abeokuta, Nigeria.
Mov Disord. 2008 Jul 30;23(10):1378-83. doi: 10.1002/mds.22087.
Despite the original description of Parkinson's disease (PD) as a disorder in which "the senses and intellect remain uninjured," there is now sufficient evidence that cognitive dysfunction does occur. This research determined the frequency, pattern, and predictors of cognitive dysfunction among 51 Nigerian patients with PD compared with 50 demographically matched controls using the modified Community Screening Instrument for Dementia (CSI'D') and selected items from the Ibadan Neuropsychological Battery (I-NB). In all, 21.6% patients with PD (4% of controls) exhibited cognitive impairment (P = 0.008) defined, for the purposes of this study, as total modified CSI'D' score below 2 SD of the mean score of the control group. Cognitive dysfunction in patients with PD encompassed memory, language, and executive dysfunction. Correlates of cognitive dysfunction included older age at PD onset (P = 0.001), older current age (P < 0.001), and higher UPDRS motor score (P = 0.005). After logistic regression, older age at onset of PD was the only independent predictor of cognitive dysfunction. (O.R = 1.29; 95% CI = 1.08-1.57, P = 0.006). Cognitive dysfunction occurs more frequently in Nigerians with PD compared to controls. Older age at disease onset is an important determinant of cognitive dysfunction in PD.
尽管帕金森病（PD）最初被描述为一种“感觉和智力未受损”的疾病，但现在有充分证据表明认知功能障碍确实会发生。本研究使用改良的社区痴呆筛查工具（CSI'D'）和伊巴丹神经心理测验组（I-NB）中的特定项目，确定了51名尼日利亚帕金森病患者与50名人口统计学匹配的对照者中认知功能障碍的频率、模式和预测因素。总体而言，21.6%的帕金森病患者（对照组为4%）表现出认知障碍（P = 0.008），在本研究中，认知障碍定义为改良后的CSI'D'总分低于对照组平均分的2个标准差。帕金森病患者的认知功能障碍包括记忆、语言和执行功能障碍。认知功能障碍的相关因素包括帕金森病发病时年龄较大（P = 0.
