Odukogbe A A, Adebamowo C A, Adeniji A O, Omigbodun A O, Olayemi O, Oladokun A, Owolabi M S, Aimakhu C, Adewole I F, Owoaje E
Ovarian Cancer Service, Gynecological Oncology Unit, Department of Obstetrics and Gynecology, College of Medicine/University College Hospital, University of Ibadan, Ibadan, Nigeria.
Afr J Med Med Sci. 2005 Sep;34(3):307-9.
The etiology of ovarian cancer has many postulates including that of incessant ovulation. Women of high parity especially those that breastfeed in addition are supposed to be protected. Ovarian cancer patients in the developing world are of higher parity than their Caucasian counterparts. Our study compared the length of reproductive career (LRC), the physiological ovulation free period (PFP) and the total ovulating period (TOP) amongst histologically proven ovarian cancer patients and age - matched controls. This is a questionnaire survey of 21 ovarian cancer patients managed by us between 1st December 1998 and 31st July 2002 and 42 gynaecological patients not known to have ovarian cancer. The mean age among the patients was 45.7+16.9 years while among the controls it was 45.4 +/- 16.1 years. The mean parity of the patients was 3.6 +/- 2.2 compared to 3.4 +/- 2.9 in the controls. The patients had a mean LRC of 23.8 +/- 11.2 years while in the controls it was 25.7+10.8 years. The mean PFP of the patients was 7.4 +/- 5.6 years and for the controls 7.1 +/- 6.5 years. The patients had a mean TOP of 15.8 +/- 8.8 years while this was 18.6 +/- 8.1 years for the controls. None of these differences was statistically significant. Our study revealed no statistically significant differences in the total ovulating periods between ovarian cancer patients and age-matched controls. Further studies will be necessary.
卵巢癌的病因有多种假说，其中包括持续排卵假说。多产妇女，尤其是那些同时进行母乳喂养的妇女，被认为受到保护。发展中世界的卵巢癌患者比白种人患者的产次更高。我们的研究比较了经组织学证实的卵巢癌患者与年龄匹配的对照组之间的生殖生涯长度（LRC）、生理性无排卵期（PFP）和总排卵期（TOP）。这是一项问卷调查，调查对象为1998年12月1日至2002年7月31日期间我们收治的21例卵巢癌患者以及42例未知患有卵巢癌的妇科患者。患者的平均年龄为45.7±16.9岁，而对照组为45.4±16.1岁。患者的平均产次为3.6±2.2，而对照组为3.4±2.9。患者的平均生殖生涯长度为23.8±11.2年，而对照组为25.7±10.8年。患者的平均生理性无排卵期为7.4±5.6年，对照组为7.1±6.5年。患者的平均总排卵期为15.8±8.8年，而对照组为18.6±8.1年。这些差异均无统计学意义。我们的研究表明，卵巢癌患者与年龄匹配的对照组之间的总排卵期没有统计学上的显著差异。有必要进行进一步的研究。
