Demopoulos R I, Seltzer V, Dubin N, Gutman E
Obstet Gynecol. 1979 Aug;54(2):150-5.
Three hundred twenty-seven patients with ovarian carcinoma were compared with matched controls to determine the association of parity and marital status with the development of ovarian cancer. Nulliparous women were found to have 2.31 times the risk of developing ovarian cancer as parous women. Unmarried women had 3 times the risk of developing ovarian cancer, but marital status was not established as a variable independent of parity. Almost 8% of patients with ovarian carcinoma had had hysterectomies when they were over 40 years of age. This study indicates that parity is an important consideration when determining whether a patient is at high risk for the development of ovarian carcinoma. Other epidemiologic variables are discussed in an effort to facilitate the judicious selection of patients for elective oophorectomy at the time of hysterectomy.
对327例卵巢癌患者与匹配的对照组进行比较，以确定生育情况和婚姻状况与卵巢癌发生之间的关联。发现未生育女性患卵巢癌的风险是已生育女性的2.31倍。未婚女性患卵巢癌的风险是已婚女性的3倍，但婚姻状况并非独立于生育情况之外的一个变量。近8%的卵巢癌患者在40岁以上时接受了子宫切除术。这项研究表明，在确定患者是否处于卵巢癌发生的高风险时，生育情况是一个重要的考虑因素。还讨论了其他流行病学变量，以便在子宫切除时明智地选择患者进行选择性卵巢切除术。
