Odajima Y, Kuwabara H
Department of Paediatrics, Saitama Medical School, Saitama, Japan.
J Int Med Res. 2006 Mar-Apr;34(2):208-14. doi: 10.1177/147323000603400211.
This epidemiological study assessed whether the use of anti-inflammatory drugs, in particular inhaled corticosteroids, affected hospitalization rates for asthma in Japan between 1990 and 2002. Asthma hospitalization rates were calculated from the number of asthma in-patients recorded in governmental surveys. Information concerning use of anti-inflammatory drugs was extracted from the IMS prescription database. Patients were stratified into four age groups: < or = 4 years, 5 - 19 years, 20 - 39 years and 40 - 64 years. Over the study period, the number of prescriptions for inhaled corticosteroids per year increased dramatically and hospitalizations for asthma decreased in all groups except those < or = 4 years of age. Increased use of leukotriene receptor antagonists was also noted in all age groups. The use of anti-inflammatory drugs may have contributed to the observed decrease in asthma hospitalizations. Increased use of inhaled corticosteroids in infants and very young children may help prevent hospitalization in this age group.
这项流行病学研究评估了1990年至2002年间，使用抗炎药物，尤其是吸入性糖皮质激素，是否会影响日本哮喘的住院率。哮喘住院率是根据政府调查中记录的哮喘住院患者数量计算得出的。有关抗炎药物使用情况的信息是从IMS处方数据库中提取的。患者被分为四个年龄组：≤4岁、5 - 19岁、20 - 39岁和40 - 64岁。在研究期间，每年吸入性糖皮质激素的处方数量急剧增加，除≤4岁年龄组外，所有年龄组的哮喘住院人数均有所下降。所有年龄组中白三烯受体拮抗剂的使用量也有所增加。抗炎药物的使用可能是观察到的哮喘住院人数下降的原因。婴儿和幼儿中吸入性糖皮质激素使用量的增加可能有助于预防该年龄组的住院情况。
