Zurn A D
Institute of Pathology, Division of Neuropathology, Lausanne, Switzerland.
Life Sci. 1991;48(19):1799-808. doi: 10.1016/0024-3205(91)90234-3.
Neuronal function can be modulated by a variety of neuronal, environmental and hormonal stimuli. One form of neuronal modulation is the change in the biosynthesis of specific neurotransmitters. This is of particular interest since neurotransmitters are the agents responsible for neuronal communication. The analysis of the long-term modulation of neurotransmitter expression in response to external factors could be a suitable model to study the possible biochemical mechanisms involved in learning and memory. Furthermore, understanding the molecular mechanisms involved in the regulation of norepinephrine synthesis in the sympathetic nervous system may be relevant for understanding stress and diseases of the cardiovascular system.
神经元功能可受到多种神经元、环境和激素刺激的调节。神经元调节的一种形式是特定神经递质生物合成的变化。这一点尤为重要，因为神经递质是负责神经元通讯的介质。分析神经递质表达对外部因素的长期调节，可能是研究学习和记忆中潜在生化机制的合适模型。此外，了解交感神经系统中去甲肾上腺素合成调节所涉及的分子机制，可能有助于理解压力和心血管系统疾病。
