Rubin Donald H, Ruley H Earl
Research Medicine, Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212, USA.
Crit Rev Eukaryot Gene Expr. 2006;16(2):155-70. doi: 10.1615/critreveukargeneexpr.v16.i2.40.
Viruses are obligate intracellular parasites that rely upon the host cell for activities essential to their life cycles. Gene-trap mutagenesis provides a rapid, genome-wide strategy to identify candidate cellular genes required for virus replication. The candidate genes provide a starting point for mechanistic studies of cellular processes that participate in the virus life cycle and may provide targets for novel antiviral therapies.
