[人格障碍遗传度的双生子研究]

[A twin study of personality disorder heritability].

作者信息

Ji Wen-yan, Hu Yong-hua, Huang Yue-qin, Cao Wei-hua, Lv Jun, Qin Ying, Pang Zeng-chang, Wang Shao-jie, Li Li-ming

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100083, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2006 Feb;27(2):137-41.

PMID:16749995

Abstract

OBJECTIVE

To calculate heritabilities of personality disorders (PDs) in twin population.

METHODS

Based on informed consent, we used Personality Diagnostic Questionnaire (fourth-version) as our screening tool to study the adult twins (aged 20 - 70 years) in Qingdao city. There were 324 twin pairs whose zygosity had been determined. Structural equation modeling was used to estimate the heritabilities by 242 same-sex twin pairs.

RESULTS

The best-fitting models yielded a heritability of 68.26% (60.26 - 74.78) of overall PDs, 59.00% (49.22 - 67.17) of cluster A, 64.99% (56.24 - 72.16) of cluster B, and 63.66% (54.72 - 71.02) of cluster C. There were significant genetic effects for schizotypal, narcissistic and dependent, explaining 49.96% (37.94 - 60.14), 52.89% (41.85 - 62.24) and 68.87% (60.80 - 75.40) of the variance respectively. No genetic effects were found on Histrionic, but common environmental effect accounted for 54.08% (44.50 - 62.43) of the total variances.

CONCLUSION

PD was mainly determined by genetic factor. These findings may provide evidence for future research on PD.

摘要

目的

计算双生子人群中人格障碍（PDs）的遗传率。

方法

在获得知情同意后，我们使用人格诊断问卷（第四版）作为筛查工具，对青岛市20至70岁的成年双胞胎进行研究。共有324对双胞胎的合子性已被确定。采用结构方程模型，通过242对同性双胞胎来估计遗传率。

结果

最佳拟合模型得出总体人格障碍的遗传率为68.26%（60.26 - 74.78），A簇为59.00%（49.22 - 67.17），B簇为64.99%（56.24 - 72.16），C簇为63.66%（54.72 - 71.02）。分裂型、自恋型和依赖型人格障碍存在显著的遗传效应，分别解释了49.96%（37.94 - 60.14）、52.89%（41.85 - 62.24）和68.87%（60.80 - 75.40）的变异。未发现表演型人格障碍有遗传效应，但共同环境效应占总变异的54.08%（44.50 - 62.43）。