Perugi G, Michelini S, Petracca A, Cassano G B
Clinica Psichiatrica II, Università degli Studi di Pisa.
Clin Ter. 1991 Apr 30;137(2):117-24.
Benzodiazepines (BDZ) are widely prescribed in clinical practice for many pathological conditions, because of their anxiolytic, sedative, myorelaxant and anticonvulsant properties. The effectiveness, specificity and rapidity of action, the few side effects and the virtual absence of toxicity, have contributed to the widespread use of these compounds. In the last decade, however, the attitude towards BDZ has greatly changed, due to growing awareness and concern about dependence liability, withdrawal phenomena, and long-term side effects. Withdrawal symptoms have been singled out and specified in the contest of a well-defined syndrome with foreseeable onset, duration and remission. Psychic and physical symptoms and disorders of sensory perception can be observed. These manifestations can be suppressed by resuming treatment. The symptomatic and developmental aspects of BDZ withdrawal syndrome are discussed, according to the available literature, with particular reference to clinical features of patients suffering from anxiety and mood disorders.
苯二氮䓬类药物（BDZ）因其抗焦虑、镇静、肌松和抗惊厥特性，在临床实践中被广泛用于多种病理状况。其作用的有效性、特异性和快速性，副作用较少且几乎没有毒性，促使了这些化合物的广泛使用。然而，在过去十年中，由于对依赖性、戒断现象和长期副作用的认识和关注不断增加，人们对BDZ的态度发生了很大变化。戒断症状已在一个具有可预见的发作、持续时间和缓解的明确综合征背景中被明确指出。可以观察到精神和身体症状以及感觉知觉障碍。这些表现可通过恢复治疗得到抑制。根据现有文献，讨论了BDZ戒断综合征的症状和发展方面，特别提及患有焦虑和情绪障碍患者的临床特征。
