Yuasa Takahito, Iwamoto Motomi Enomoto
Thomas Jefferson University, Department of Orthopaedic Surgery.
Clin Calcium. 2006 Jun;16(6):1034-39.
Wnt proteins play central roles in a variety of developmental processes and regulate cell differentiation, cell fate and cell proliferation. It has been also demonstrated that Wnt proteins profoundly participate in cartilage development. Interestingly, activation of Wnt/beta-catenin signaling in chondrocytes induces a profile of matrix degradation enzymes quite similar to that of cartilage matrix degradation such as osteoarthritis and rheumatoid arthritis. In this review we discuss the involvement of Wnt/beta-catenin signaling in pathological cartilage matrix degradation.
Wnt蛋白在多种发育过程中发挥核心作用，并调节细胞分化、细胞命运和细胞增殖。研究还表明，Wnt蛋白在软骨发育中也发挥着重要作用。有趣的是，软骨细胞中Wnt/β-连环蛋白信号的激活会诱导出与骨关节炎和类风湿关节炎等软骨基质降解非常相似的基质降解酶谱。在这篇综述中，我们讨论了Wnt/β-连环蛋白信号在病理性软骨基质降解中的作用。
