炎症化学介质导致鸟嘌呤氧化的矛盾热点。
Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation.
作者信息
Margolin Yelena, Cloutier Jean-Francois, Shafirovich Vladimir, Geacintov Nicholas E, Dedon Peter C
机构信息
Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
出版信息
Nat Chem Biol. 2006 Jul;2(7):365-6. doi: 10.1038/nchembio796. Epub 2006 Jun 4.
Guanine in DNA is a major oxidation target owing to its low ionization potential (IP), and there is often an inverse correlation between damage frequency and sequence-dependent variation in guanine IP. We report that the biological oxidant nitrosoperoxycarbonate (ONOOCO2(-)) paradoxically selects guanines with the highest IP in GC-containing contexts. Along with sequence-dependent variation in damage chemistry, this behavior points to factors other than charge migration as determinants of genomic DNA oxidation.
由于鸟嘌呤的电离电位较低，DNA中的鸟嘌呤是主要的氧化靶点，并且损伤频率与鸟嘌呤电离电位的序列依赖性变化之间通常存在负相关。我们报告称，生物氧化剂亚硝基过氧碳酸盐（ONOOCO2(-)）反常地在含鸟嘌呤-胞嘧啶的环境中选择电离电位最高的鸟嘌呤。除了损伤化学的序列依赖性变化外，这种行为还表明电荷迁移以外的因素是基因组DNA氧化的决定因素。
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