Martin S, Rothe H, Tschöpe D, Schwippert B, Kolb H
Diabetes Research Institute, Heinrich Heine, University of Düsseldorf, Germany.
Immunology. 1991 May;73(1):123-5.
The expression of adhesion molecules in monocytes of patients with recent onset type I diabetes was analysed. Monocytes were identified as CD14-positive cells by flow cytometry. The percentage of monocytes expression LFA-1 alpha, ICAM-1 and HLA-DR was slightly lower in recent onset type I diabetes (n = 13) compared to normal subjects (n = 15) and was significantly decreased after activation of cells with lipopolysaccharide and interferon-gamma for 5-24 hr. Receptor densities on adhesion molecule-positive monocytes and the expression of LFA-1 beta were normal. These data indicate that monocyte trafficking is abnormal in recent onset type 1 diabetes.
分析了近期发病的1型糖尿病患者单核细胞中黏附分子的表达情况。通过流式细胞术将单核细胞鉴定为CD14阳性细胞。与正常受试者（n = 15）相比，近期发病的1型糖尿病患者（n = 13）中表达淋巴细胞功能相关抗原-1α（LFA-1α）、细胞间黏附分子-1（ICAM-1）和人类白细胞抗原-DR（HLA-DR）的单核细胞百分比略低，在用脂多糖和干扰素-γ激活细胞5 - 24小时后显著降低。黏附分子阳性单核细胞上的受体密度以及LFA-1β的表达正常。这些数据表明近期发病的1型糖尿病患者单核细胞的迁移异常。
