Talman W T, Robertson S C
Department of Neurology, University of Iowa College of Medicine, Iowa City.
Hypertension. 1991 Jun;17(6 Pt 2):1173-6. doi: 10.1161/01.hyp.17.6.1173.
Electrical stimulation of fibers of passage through the fastigial nucleus increases arterial pressure. To identify nuclei that may project through the pressor region of the fastigial nucleus, we injected the retrograde tracer fast blue unilaterally at confirmed pressor sites in the nucleus. In seven rats, we found dense fluorescent labeling bilaterally in the external cuneate, lateral reticular, medial vestibular, and caudal prepositus hypoglossi nuclei, and contralaterally in the inferior olivary nucleus. There had been no reports of a cardiovascular role for the nucleus prepositus hypoglossi; thus, we sought to determine if electrical or chemical stimulation of that nucleus or the adjacent medial vestibular nucleus altered arterial pressure or heart rate in 24 anesthetized rats. Both types of stimuli to the caudal, but not the rostral, pole of the nucleus prepositus hypoglossi or to the medial vestibular nucleus elicited an increase in arterial pressure; bradycardia accompanied the former and tachycardia the latter. Both the nucleus prepositus hypoglossi and medial vestibular nucleus may participate in central cardiovascular regulation.
电刺激通过顶核的纤维束会使动脉血压升高。为了确定可能通过顶核升压区域投射的核团，我们在顶核中已确认的升压部位单侧注射逆行示踪剂快蓝。在7只大鼠中，我们发现双侧楔外核、外侧网状核、内侧前庭核和舌下前置核尾部有密集的荧光标记，对侧下橄榄核也有荧光标记。此前尚无关于舌下前置核在心血管方面作用的报道；因此，我们试图确定对该核团或相邻的内侧前庭核进行电刺激或化学刺激是否会改变24只麻醉大鼠的动脉血压或心率。对舌下前置核尾部而非头部极点或内侧前庭核的两种刺激均引起动脉血压升高；前者伴有心动过缓，后者伴有心动过速。舌下前置核和内侧前庭核可能都参与中枢心血管调节。
