Ott H, Baron J, Merk H F
Klinik für Dermatologie und Allergologie, Universitäts-Hautklinik, Aachen.
Hautarzt. 2006 Jun;57(6):502, 504-8. doi: 10.1007/s00105-006-1167-y.
Along with the history, skin tests and provocation tests, in vitro test procedures are essential for the adequate care for patients with allergies. While serological investigations of immediate-type allergic reactions primarily detect allergen-specific IgE antibodies, basophil activation tests with different read-out parameters are available for cellular diagnosis of immediate-type reaction patterns. If clinically necessary, further immunological methods (i. e. immunoblots, lymphocyte transformation tests) can be employed. New options are provided by allergen microarray technology, which makes it possible to determine not only the specific antigenic protein but also to analyze different epitopes.
除病史、皮肤试验和激发试验外，体外检测程序对于为过敏患者提供充分护理至关重要。虽然对速发型过敏反应的血清学研究主要检测过敏原特异性IgE抗体，但具有不同读数参数的嗜碱性粒细胞活化试验可用于速发型反应模式的细胞诊断。如有临床必要，可采用进一步的免疫学方法（即免疫印迹、淋巴细胞转化试验）。过敏原微阵列技术提供了新的选择，它不仅可以确定特定的抗原蛋白，还可以分析不同的表位。
