Emmerson B T
University of Queensland, Department of Medicine, Princess Alexandra Hospital, Brisbane, Australia.
Lancet. 1991 Jun 15;337(8755):1461-3. doi: 10.1016/0140-6736(91)93141-u.
Accurate identification of the factors that contribute to hyperuricaemia in an individual may enable some of these factors to be modified, and lead to permanent correction of the hyperuricaemia. A protocol is described which can supplement clinical assessment. Measurement of the effects on serum urate and urinary urate excretion of a low-purine diet for 7 days facilitates the identification of the contributions made by urate production (either endogenous or from purine consumption) and renal underexcretion of urate (either as a low urate clearance in the absence of renal disease or due to renal glomerular insufficiency).
准确识别个体中导致高尿酸血症的因素，可能会使其中一些因素得到改善，并最终实现高尿酸血症的永久性纠正。本文描述了一种可辅助临床评估的方案。通过测量低嘌呤饮食7天对血清尿酸盐和尿尿酸盐排泄的影响，有助于确定尿酸生成（内源性或因嘌呤摄入）以及肾脏尿酸排泄不足（无肾脏疾病时尿酸清除率低或因肾小球功能不全）所起的作用。
