Liu Yi, Montminy Marc
The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
Cell Metab. 2006 Jun;3(6):387-8. doi: 10.1016/j.cmet.2006.05.006.
The nuclear hormone receptor coactivator PGC-1alpha is a key regulator of gluconeogenic genes during fasting. In this issue of Cell Metabolism, Puigserver and colleagues (Lerin et al., 2006) report that the histone acetyltransferase GCN5 inhibits gluconeogenesis by acetylating and sequestering PGC-1alpha in nuclear foci.
核激素受体辅激活因子PGC-1α是禁食期间糖异生基因的关键调节因子。在本期《细胞代谢》中，普伊格塞尔弗及其同事（勒林等人，2006年）报告称，组蛋白乙酰转移酶GCN5通过使PGC-1α乙酰化并将其隔离在核灶中来抑制糖异生。
