Dolu Nazan, Ozesmi Cigdem, Comu Nurdan, Süer Cem, Gölgeli Asuman
University of Erciyes Faculty of Medicine Department of Physiology, Kayseri, Turkey.
Int J Neurosci. 2006 Jun;116(6):715-29. doi: 10.1080/00207450600675027.
This study investigated the relationship between hyperglycemia and electrodermal activity (EDA) parameters in streptozotocin (STZ) induced diabetic rats. The article evaluates the course of development of neurophysiological alterations in the peripheral nervous system in diabetic rats through EDA. Rats were made diabetic using a moderate dose of STZ (DI) and high dose (DII). The placebo group (P) was injected with physiological saline. EDA was recorded 1 h before the injection (beginning, 0, day), 1st day (one day after the injection) and 10th day. Skin conductance level (SCL) was lower in DII than P on the 1st and the 10th days. The SCL and SC fluctuation rate (SCFr) of DI were significantly lower on the 10th day compared to their first record. SC response rate (SCRr) was lower on the 10th day compared to the 1st day, in the DI. In the DI, SCL, SC fluctuation rate (SCFr) and SC response rate (SCRr) were lower on the 10th day compared to the 1st day. The DII was statistically higher in electrodermal non-responsiveness compared to other groups on the 1st day. The results obtained show that hyperglycemia affects the peripheral nervous system, and EDA parameters are affected by blood glucose level. It is suggested that EDA is a simple and non-invasive electrophysiological method in early diagnosis of diabetic neuropathy.
本研究调查了链脲佐菌素（STZ）诱导的糖尿病大鼠高血糖与皮肤电活动（EDA）参数之间的关系。本文通过EDA评估糖尿病大鼠外周神经系统神经生理改变的发展过程。使用中等剂量的STZ（DI组）和高剂量（DII组）使大鼠患糖尿病。安慰剂组（P组）注射生理盐水。在注射前1小时（开始，第0天）、第1天（注射后一天）和第10天记录EDA。在第1天和第10天，DII组的皮肤电导水平（SCL）低于P组。与首次记录相比，DI组在第10天的SCL和皮肤电导波动率（SCFr）显著降低。在DI组中，第10天的皮肤电导反应率（SCRr）低于第1天。在DI组中，第10天的SCL、皮肤电导波动率（SCFr）和皮肤电导反应率（SCRr）均低于第1天。在第1天DII组的皮肤电无反应性在统计学上高于其他组。所得结果表明，高血糖会影响外周神经系统，且EDA参数受血糖水平影响。建议EDA是糖尿病神经病变早期诊断中一种简单且无创的电生理方法。
