Ukkola Olavi, Pöykkö Seppo M, Antero Kesäniemi Y
Department of Internal Medicine, University of Oulu, Finland.
Ann Med. 2006;38(4):274-9. doi: 10.1080/07853890600622192.
Low ghrelin concentration has been associated with several features of metabolic syndrome (MS), but the relationship between ghrelin concentration and MS as a cluster of metabolic aberrations has not yet been studied.
To analyse whether ghrelin concentration is associated with MS.
Fasting plasma ghrelin concentrations of the population-based cohort of 1037 middle-aged men and women were analysed using a commercial radioimmunoassay kit (Phoenix Peptide). MS was determined using the new International Diabetes Federation criteria.
The prevalence of MS was 37.2%. The ghrelin concentrations were decreased in subjects with MS (635 pg/mL) compared to those without MS (687 pg/mL) (P=0.001). Ghrelin levels decreased with an increase in the number of metabolic abnormalities. Low ghrelin was a statistically significant predictor of MS in logistic regression analysis (P=0.005) so that the subjects in the 1st ghrelin quartile were at higher risk of having MS compared to the subjects in the 4th quartile (OR=1.82, 95% CI: 1.27-2.60, P=0.001). This association remained statistically significant after adjustment for age and sex (OR=1.76, 95% CI: 1.24-2.55, P=0.002).
Metabolic syndrome is associated with low ghrelin levels suggesting a relationship of ghrelin in the metabolic disturbances of MS.
低胃饥饿素浓度与代谢综合征（MS）的多种特征相关，但胃饥饿素浓度与作为一组代谢异常的MS之间的关系尚未得到研究。
分析胃饥饿素浓度是否与MS相关。
使用商用放射免疫分析试剂盒（Phoenix Peptide）分析了1037名基于人群的中年男性和女性队列的空腹血浆胃饥饿素浓度。采用新的国际糖尿病联盟标准确定MS。
MS的患病率为37.2%。与无MS者（687 pg/mL）相比，MS患者的胃饥饿素浓度降低（635 pg/mL）（P=0.001）。胃饥饿素水平随代谢异常数量的增加而降低。在逻辑回归分析中，低胃饥饿素是MS的统计学显著预测因子（P=0.005），因此与第四四分位数的受试者相比，第一四分位数的受试者患MS的风险更高（OR=1.82，95%CI：1.27-2.60，P=0.001）。在调整年龄和性别后，这种关联仍然具有统计学显著性（OR=1.76，95%CI：1.24-2.55，P=0.002）。
代谢综合征与低胃饥饿素水平相关，提示胃饥饿素在MS代谢紊乱中存在关联。
