Karlsson L, Surh C D, Sprent J, Peterson P A
Department of Immunology, Scrips Clinic and Research Foundation, La Jolla, California 92037.
Nature. 1991 Jun 6;351(6326):485-8. doi: 10.1038/351485a0.
The repertoire of mature class II-restricted T cells is generated through a complex process of selection whereby early T cells confront class II molecules in the thymus, especially on epithelial cells. Expression of class II molecules on such cells is prominent both in the cortex and in the medulla. We have identified a novel class II molecule, H-20, which is expressed only in epithelial cells of the thymic medulla and in B cells. The unusual tissue distribution and the nonpolymorphic nature of H-20 suggest that its function is different from that of classical class II molecules.
成熟的II类限制性T细胞库是通过一个复杂的选择过程产生的，在此过程中，早期T细胞在胸腺中，尤其是在上皮细胞上，与II类分子相互作用。此类细胞上II类分子的表达在皮质和髓质中都很显著。我们鉴定出一种新的II类分子H-20，它仅在胸腺髓质的上皮细胞和B细胞中表达。H-20不同寻常的组织分布和非多态性表明其功能与经典II类分子不同。
