Farr A G, Sidman C L
J Immunol. 1984 Jul;133(1):98-103.
Thymic Ia antigen expression was examined with biochemical and immunohistochemical techniques. We found that expression of Ia antigens was reduced in thymic tissue of aged mice and that much of this loss was associated with cortical thymic epithelial cells. The ontologic pattern of Ia antigen expression in the thymus closely followed that observed for thymic weight, reaching maximal values at 4 wk of age and declining thereafter.
采用生化和免疫组织化学技术检测胸腺Ia抗原的表达。我们发现，老年小鼠胸腺组织中Ia抗原的表达降低，且这种降低大部分与皮质胸腺上皮细胞有关。胸腺中Ia抗原表达的发育模式与胸腺重量的变化密切相关，在4周龄时达到最大值，之后下降。
