Kamphorst W, Gao Y Z, van Alphen H A
Department of Neurosurgery, Free University Hospital, Amsterdam, The Netherlands.
Neurol Res. 1991 Mar;13(1):55-9. doi: 10.1080/01616412.1991.11739965.
Although the reason for development of saccular aneurysms in humans has still not been elucidated, the process might be observed and explained using a reproducible aneurysm model in vivo. In this paper, a sequential pathological study of the experimental saccular aneurysms was made. No additional influential factors were applied. At all stages of the development between the induction and 6 months, the histology of the aneurysm wall was similar to that of human aneurysms. The imbalance of the degeneration and regeneration processes during the development of these experimental aneurysms is discussed according to the pathological findings in different periods. Haemodynamic stress and different regenerative speeds in different arterial tissues must be responsible for the saccular aneurysm formation and growth.
尽管人类囊状动脉瘤的发病原因仍未阐明，但该过程可通过体内可重复的动脉瘤模型进行观察和解释。本文对实验性囊状动脉瘤进行了连续的病理学研究。未施加额外的影响因素。在诱导后至6个月的所有发育阶段，动脉瘤壁的组织学与人类动脉瘤相似。根据不同时期的病理结果，讨论了这些实验性动脉瘤发育过程中退变与再生过程的失衡。血流动力学应力和不同动脉组织中不同的再生速度必定是囊状动脉瘤形成和生长的原因。
