Szymanski S, Kane J M, Lieberman J A
Psychiatry Research Department, Hillside Hospital, Glen Oaks, NY 11004.
Schizophr Bull. 1991;17(1):99-111. doi: 10.1093/schbul/17.1.99.
Through previous research, promising biological markers for schizophrenia have been identified. Abnormalities in eye movement, electrodermal activity, event-related brain potentials, attention and informational processing, and brain imaging have been reported. Studies of potential trait markers suffer from the lack of a standardized methodology, which makes comparisons of their results difficult. No one possible marker appears specific for schizophrenia. Additional studies in high-risk children and adults are needed using multiple measurements to define biologic similarities and differences between psychiatric syndromes in order to develop definitive trait markers for schizophrenia. Sufficient evidence does not exist to support the inclusion of biological markers among the DSM-IV criteria for schizophrenia, although some are sufficiently robust to merit mention among the associated features discussed in the text.
通过先前的研究，已确定了有前景的精神分裂症生物标志物。已有报告称眼动、皮肤电活动、事件相关脑电位、注意力和信息处理以及脑成像存在异常。对潜在特质标志物的研究因缺乏标准化方法而受到影响，这使得对其结果进行比较变得困难。没有一种可能的标志物似乎对精神分裂症具有特异性。需要对高危儿童和成人进行更多研究，采用多种测量方法来确定精神疾病综合征之间的生物学异同，以便开发出精神分裂症的确切特质标志物。虽然有一些生物标志物足够可靠，值得在文本讨论的相关特征中提及，但尚无充分证据支持将其纳入精神分裂症的《精神疾病诊断与统计手册》第四版标准。
