Alder Lutz, Greulich Kerstin, Kempe Günther, Vieth Bärbel
Federal Institute for Risk Assessment, Residue Analysis Unit, Thielallee 88-92, 14195 Berlin, Germany.
Mass Spectrom Rev. 2006 Nov-Dec;25(6):838-65. doi: 10.1002/mas.20091.
This overview evaluates the capabilities of mass spectrometry (MS) in combination with gas chromatography (GC) and liquid chromatography (LC) for the determination of a multitude of pesticides. The selection of pesticides for this assessment is based on the status of production, the existence of regulations on maximum residue levels in food, and the frequency of residue detection. GC-MS with electron impact (EI) ionization and the combination of LC with tandem mass spectrometers (LC-MS/MS) using electrospray ionization (ESI) are identified as techniques most often applied in multi-residue methods for pesticides at present. Therefore, applicability and sensitivity obtained with GC-EI-MS and LC-ESI-MS/MS is individually compared for each of the selected pesticides. Only for one substance class only, the organochlorine pesticides, GC-MS achieves better performance. For all other classes of pesticides, the assessment shows a wider scope and better sensitivity if detection is based on LC-MS.
本综述评估了质谱（MS）与气相色谱（GC）和液相色谱（LC）联用测定多种农药的能力。本次评估所选用的农药是基于其生产状况、食品中最大残留限量的法规情况以及残留检测频率。目前，具有电子轰击（EI）电离的气相色谱-质谱联用（GC-MS）以及使用电喷雾电离（ESI）的液相色谱与串联质谱仪联用（LC-MS/MS）被确定为农药多残留方法中最常用的技术。因此，针对每种选定的农药，分别比较了GC-EI-MS和LC-ESI-MS/MS的适用性和灵敏度。仅对于一类物质，即有机氯农药，GC-MS具有更好的性能。对于所有其他类别的农药，评估表明，如果基于LC-MS进行检测，则检测范围更广且灵敏度更高。
