Fujita H, Morita I, Murota S
Section of Physiological Chemistry, School of Dentistry, Tokyo Medical and Dental University, Japan.
Biochem Biophys Res Commun. 1991 Jun 14;177(2):664-72. doi: 10.1016/0006-291x(91)91840-9.
Protective effect of anti-CD11a and anti-ICAM-1 antibodies on the cytotoxicity induced by PMA-stimulated neutrophils was studied using cultured endothelial cells isolated from bovine carotid artery. Anti-CD11a antibody and anti-ICAM-1 antibody inhibited the endothelial cell injury induced by the activated neutrophils in a dose dependent manner. On the other hand, both antibodies themselves had no effect on either the luminol chemiluminescence released out of the activated neutrophils or the adhesion of the neutrophils to the endothelial cell monolayer. These data suggest that these adhesion molecules play some important roles in the vascular endothelial cell injury elicited by activated neutrophils.
利用从牛颈动脉分离的培养内皮细胞，研究了抗CD11a和抗ICAM - 1抗体对佛波酯（PMA）刺激的中性粒细胞诱导的细胞毒性的保护作用。抗CD11a抗体和抗ICAM - 1抗体以剂量依赖性方式抑制活化中性粒细胞诱导的内皮细胞损伤。另一方面，两种抗体本身对活化中性粒细胞释放的鲁米诺化学发光或中性粒细胞与内皮细胞单层的黏附均无影响。这些数据表明，这些黏附分子在活化中性粒细胞引起的血管内皮细胞损伤中起一些重要作用。
