Biffl W L, Moore E E, Moore F A, Peterson V M
Department of Surgery, Denver General Hospital, Colorado 80204, USA.
Ann Surg. 1996 Nov;224(5):647-64. doi: 10.1097/00000658-199611000-00009.
The effects of interleukin (IL)-6 in the injured patient are examined in an attempt to clarify the potential pathophysiologic role of IL-6 in the response to injury.
Interleukin-6 is an integral cytokine mediator of the acute phase response to injury and infection. However, prolonged and excessive elevations of circulating IL-6 levels in patients after trauma, burns, and elective surgery have been associated with complications and mortality. The mechanistic role of IL-6 in mediating these effects is unclear.
A review of current literature is performed to summarize the origins, mechanisms of action, and biologic effects of IL-6 and to characterize the IL-6 response to injury.
Interleukin-6 is a multifunctional cytokine expressed by a variety of cells after a multitude of stimuli, under complex regulatory control mechanisms. The IL-6 response to injury is uniquely consistent and related to the magnitude of the insult. Moreover, the early postinjury IL-6 response correlates with complications as well as mortality.
Interleukin-6 appears to play an active role in the postinjury immune response, making it an attractive therapeutic target in attempts to control hyperinflammatory provoked organ injury.
研究白细胞介素（IL）-6在受伤患者中的作用，以阐明IL-6在损伤反应中潜在的病理生理作用。
白细胞介素-6是损伤和感染急性期反应中不可或缺的细胞因子介质。然而，创伤、烧伤和择期手术后患者循环中IL-6水平的长期过度升高与并发症及死亡率相关。IL-6介导这些效应的机制尚不清楚。
对当前文献进行综述，以总结IL-6的来源、作用机制和生物学效应，并描述IL-6对损伤的反应。
白细胞介素-6是一种多功能细胞因子，在多种复杂调控机制下，多种细胞在受到多种刺激后均可表达。IL-6对损伤的反应具有独特的一致性，且与损伤程度相关。此外，伤后早期IL-6反应与并发症及死亡率相关。
白细胞介素-6似乎在伤后免疫反应中发挥积极作用，使其成为控制过度炎症引发的器官损伤的一个有吸引力的治疗靶点。
