高渗溶液诱发的主动脉张力增强是内皮依赖性的。

Enhancement of aorta tonus evoked by hypertonic solutions is endothelium-dependent.

Scivoletto R, Fortes Z B, Nigro D, Lopes O U, de Carvalho M H

Department of Pharmacology, University of São Paulo, Brazil.

Gen Pharmacol. 1991;22(1):133-6. doi: 10.1016/0306-3623(91)90323-x.

Abstract

The effect of NaCl hypertonic solutions on the contractions induced by noradrenaline or prostaglandin F2 alpha and on the relaxant effect of acetylcholine and sodium nitroprusside was investigated in aortae with or without endothelium isolated from rats. 2. Hypertonic solutions enhanced the contractions elicited by the vasoconstrictor agents in preparations with endothelium and this phenomenon was not altered by previous treatment of the animals with reserpine or the preparations with methylene blue or indomethacin. 3. In hypertonic medium acetylcholine but not sodium nitroprusside vasodilator effect was inhibited. 4. We suggest that NaCl hypertonic solutions modify vascular reactivity probably through: (i) the release of an endothelium-derived contracting factor not sensitive to cyclooxygenase inhibitors; (ii) a diminished release of an endothelium-derived relaxing factor not related to the cGMP system.

摘要

研究了氯化钠高渗溶液对去甲肾上腺素或前列腺素F2α诱导的收缩以及乙酰胆碱和硝普钠舒张作用的影响，实验对象为从大鼠分离的有或无内皮的主动脉。2. 高渗溶液增强了有内皮制剂中血管收缩剂引起的收缩，并且这种现象不因事先用利血平处理动物或用亚甲蓝或吲哚美辛处理制剂而改变。3. 在高渗介质中，乙酰胆碱的血管舒张作用受到抑制，但硝普钠的作用未受影响。4. 我们认为，氯化钠高渗溶液可能通过以下方式改变血管反应性：（i）释放一种对环氧合酶抑制剂不敏感的内皮源性收缩因子；（ii）减少一种与环鸟苷酸系统无关的内皮源性舒张因子的释放。