去甲肾上腺素在正常血压大鼠中诱导内皮衍生舒张因子和收缩因子的同时释放。
Simultaneous release of endothelium-derived relaxing and contracting factors induced by noradrenaline in normotensive rats.
作者信息
Nigro D, Fortes Z B, Scivotetto R, Carvalho M H
机构信息
Department of Pharmacology, University of São Paulo, Brazil.
出版信息
Gen Pharmacol. 1990;21(4):443-6. doi: 10.1016/0306-3623(90)90695-i.
PMID:2199298
Abstract
- Noradrenaline produced a biphasic response in indomethacin (10(-5) M)-treated aorta isolated from normotensive rats. 2. The relaxation phase is enhanced by previous treatment of the animals with estrogen. 3. Blockade of the relaxant effect elicited by supramaximal concentration of noradrenaline was observed when 10(-5) M of methylene blue was present in the bathing fluid for 15 min. 4. Noradrenaline caused a simultaneous release of endothelium-derived relaxing and contracting factors in aorta from normotensive rats.
摘要
- 去甲肾上腺素对从正常血压大鼠分离出的经吲哚美辛（10⁻⁵ M）处理的主动脉产生双相反应。2. 动物预先用雌激素处理可增强舒张期反应。3. 当在浴液中加入10⁻⁵ M亚甲蓝15分钟时，观察到去甲肾上腺素超最大浓度引起的舒张效应被阻断。4. 去甲肾上腺素可同时释放正常血压大鼠主动脉中内皮源性舒张因子和收缩因子。
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