Costantino David, Lowe Lori, Brown David L
Division of Plastic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
J Plast Reconstr Aesthet Surg. 2006;59(4):424-8. doi: 10.1016/j.bjps.2005.06.007.
Basosquamous carcinoma of the skin is a relatively rare cutaneous neoplasm that has been shown to have significant metastatic potential. Histopathologists debate whether these lesions arise de novo or differentiate from pre-existing basal cell carcinomas. We present a case in which a longstanding lesion initially diagnosed as basal cell carcinoma was later found to have basosquamous histology and regional metastases. Review of the literature reveals a metastatic rate greater than that of basal cell and squamous cell carcinoma, and identifies several important characteristics that impact prognosis after surgical resection. For physicians treating carcinomas of the skin, it is important to understand the natural history and proper treatment of this aggressive neoplasm.
皮肤基底鳞状细胞癌是一种相对罕见的皮肤肿瘤，已被证明具有显著的转移潜能。组织病理学家们在争论这些病变是原发产生还是由先前存在的基底细胞癌分化而来。我们报告一例病例，一个长期存在的病变最初被诊断为基底细胞癌，后来发现具有基底鳞状组织学特征并伴有区域转移。文献回顾显示其转移率高于基底细胞癌和鳞状细胞癌，并确定了几个影响手术切除后预后的重要特征。对于治疗皮肤癌的医生来说，了解这种侵袭性肿瘤的自然病史和恰当治疗方法很重要。
