Byrne D J, Napier A, Phillips G, Cuschieri A
Department of Surgery, Ninewells Hospital and Medical School, Dundee.
J Hosp Infect. 1991 Mar;17(3):217-22. doi: 10.1016/0195-6701(91)90233-x.
Bacterial skin flora were studied in two groups of patients having three showers with either a 4% chlorhexidine detergent solution (Group A, N = 57) or a placebo detergent (Group B, N = 58). Previous reports on the efficacy of chlorhexidine in decreasing bacterial counts on the skin were confirmed and the time taken to recolonization (median 5 days; range 1-10 days) was in broad agreement with previous reports. However, concern regarding the colonization of the skin of the patients in the chlorhexidine group by potential pathogens during the recolonization period appears unfounded as there was no significant difference in the incidence of non-resident skin flora between the chlorhexidine (17/57; 30%) and the placebo (14/58; 24%) groups. These non-residents are generally lost from the skin before discharge in the chlorhexidine group but nine patients in the placebo group had abnormal skin flora at discharge from hospital. All those patients tested after discharge had lost the non-resident flora within 2 weeks of discharge. The results of this study indicate that recolonization of the skin after whole body disinfection does not present a clinical problem.
对两组患者的皮肤细菌菌群进行了研究，这两组患者分别使用4%氯己定洗涤剂溶液（A组，N = 57）或安慰剂洗涤剂（B组，N = 58）进行了三次淋浴。先前关于氯己定降低皮肤细菌数量功效的报道得到了证实，重新定植所需时间（中位数5天；范围1 - 10天）与先前报道基本一致。然而，关于氯己定组患者在重新定植期间潜在病原体在皮肤上定植的担忧似乎没有根据，因为氯己定组（17/57；30%）和安慰剂组（14/58；24%）非常驻皮肤菌群的发生率没有显著差异。在氯己定组中，这些非常驻菌通常在出院前从皮肤消失，但安慰剂组有9名患者在出院时皮肤菌群异常。所有出院后接受检测的患者在出院后2周内非常驻菌群均已消失。本研究结果表明，全身消毒后皮肤的重新定植不存在临床问题。
