Rotter M L, Larsen S O, Cooke E M, Dankert J, Daschner F, Greco D, Grönross P, Jepsen O B, Lystad A, Nyström B
Hygiene Institute of University, Vienna, Austria.
J Hosp Infect. 1988 May;11(4):310-20. doi: 10.1016/0195-6701(88)90083-7.
In a prospective, randomized, double-blind, placebo-controlled study involving 27 surgical units in six European countries, the effect of preoperative whole-body bathing on two occasions with a detergent containing chlorhexidine (CHX+) on the incidence of wound infection in elective, clean surgery was compared with two bathings with a detergent without chlorhexidine (CHX-). In the CHX+ group 2.62% of 1413 patients and in the CHX- group 2.36% of 1400 patients subsequently became infected. The infection rate in the CHX+ group was 1.11 times that in the CHX- group with 95% confidence limits ranging between 0.69 and 1.82. Consequently, bathing patients twice preoperatively with chlorhexidine-detergent did not reduce the incidence of infection of clean wounds.
在一项涉及欧洲六个国家27个外科手术单元的前瞻性、随机、双盲、安慰剂对照研究中，将术前两次使用含氯己定洗涤剂全身沐浴（CHX+）对择期清洁手术伤口感染发生率的影响，与两次使用不含氯己定洗涤剂全身沐浴（CHX-）进行了比较。CHX+组1413例患者中有2.62%随后发生感染，CHX-组1400例患者中有2.36%随后发生感染。CHX+组的感染率是CHX-组的1.11倍，95%置信区间在0.69至1.82之间。因此，术前用氯己定洗涤剂给患者沐浴两次并不能降低清洁伤口的感染发生率。
