Sachs Jonathan N, Engelman Donald M
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA.
Annu Rev Biochem. 2006;75:707-12. doi: 10.1146/annurev.biochem.75.110105.142336.
In our review, we introduce an organizational scheme for membrane protein function. It is the relationship between structure, dynamics, and environment that endows the membrane and its constituents with remarkable sensitivity and robustness. Our understanding begins with landmark advances like those presented in the following chapters. Membrane proteins are notoriously difficult to study, and so the work presented here on the ADP/ATP carrier [Nury et al. ( 2 )], rhodopsin [Palczewski ( 24 )], and the cytochrome b6f complex [Cramer et al. ( 35 )] represents incredible progress in this now blossoming field.
在我们的综述中，我们介绍了一种膜蛋白功能的组织架构。正是结构、动力学和环境之间的关系赋予了膜及其成分显著的敏感性和稳健性。我们的理解始于如下各章中介绍的具有里程碑意义的进展。膜蛋白向来难以研究，因此本文中关于ADP/ATP载体[Nury等人（2）]、视紫红质[Palczewski（24）]以及 Cytb6f 复合物[Cramer等人（35）]的研究成果代表了这个蓬勃发展的领域取得的惊人进展。
