厄他培南与其他九种对照药物对337株厌氧菌的体外活性评估。

Evaluation of the in vitro activity of ertapenem and nine other comparator agents against 337 anaerobic bacteria.

作者信息

Behra-Miellet J, Dubreuil L, Calvet L

机构信息

Faculté de Pharmacie, 3 rue du Professeur Laguesse, BP83, 59006 Lille Cedex, France.

出版信息

Int J Antimicrob Agents. 2006 Jul;28(1):25-35. doi: 10.1016/j.ijantimicag.2006.01.011. Epub 2006 Jun 6.

DOI:10.1016/j.ijantimicag.2006.01.011

PMID:16757152

Abstract

Ertapenem activity in vitro was compared with that of nine reference antibiotics against 337 anaerobes by determining minimal inhibition concentrations (MICs). Amongst 246 Gram-negative anaerobes, 4, 8, 3, 4, 7, 2 and 52 strains showed resistance to ertapenem, amoxicillin/clavulanic acid, ticarcillin/clavulanic acid, piperacillin/tazobactam, cefoxitin, imipenem and clindamycin, respectively, and all strains were inhibited by metronidazole. Ertapenem MIC(50) values were 0.5, 0.25, 0.06 and <or=0.03mg/L for the Bacteroides fragilis group, Prevotella spp., fusobacteria and Gram-positive cocci, respectively. Overall resistance rates were 2.1%, 51.3%, 2.4%, 1.2%, 1.5%, 7.1%, 0.6%, 22% and 1.5% for ertapenem, amoxicillin, amoxicillin/clavulanic acid, ticarcillin/clavulanic acid, piperacillin/tazobactam, cefoxitin, imipenem, clindamycin and metronidazole, respectively. Ertapenem showed a broad spectrum and good activity against anaerobes.

摘要

通过测定最低抑菌浓度（MICs），将厄他培南的体外活性与九种参考抗生素对337株厌氧菌的活性进行了比较。在246株革兰氏阴性厌氧菌中，分别有4、8、3、4、7、2和52株对厄他培南、阿莫西林/克拉维酸、替卡西林/克拉维酸、哌拉西林/他唑巴坦、头孢西丁、亚胺培南和克林霉素耐药，所有菌株均被甲硝唑抑制。对于脆弱拟杆菌属、普雷沃菌属、梭杆菌属和革兰氏阳性球菌，厄他培南的MIC（50）值分别为0.5、0.25、0.06和≤0.03mg/L。厄他培南、阿莫西林、阿莫西林/克拉维酸、替卡西林/克拉维酸、哌拉西林/他唑巴坦、头孢西丁、亚胺培南、克林霉素和甲硝唑的总体耐药率分别为2.1%、51.3%、2.4%、1.2%、1.5%、7.1%、0.6%、22%和1.5%。厄他培南对厌氧菌显示出广谱且良好的活性。